Research Articles
The Molecular Rebel: How an Unstable Particle Revolutionized Drug Discovery
Explore the fascinating story of trimethylenemethane (TMM), its [3+2] cycloaddition reactions, and how this once-theoretical molecule transformed pharmaceutical synthesis.
Nature's Secret Shortcut: The FAD-Driven Magic Behind Life's Complex Molecules
Discover how FAD-dependent enzymes catalyze intermolecular [4+2] cycloadditions to create complex natural products like antibiotics and anti-cancer drugs.
Click Chemistry: How 4-Pyridones Supercharge Molecular Construction
Explore the fascinating reactivity of substituted 4-pyridones in Diels-Alder cycloadditions and their applications in pharmaceutical chemistry and materials science.
The Unseen Reactors: How Nitrilium Betaines Power Modern Chemistry
Explore the fascinating world of nitrilium betaine 1,3-dipoles - the hidden powerhouses driving modern organic chemistry, drug discovery, and materials science.
Crafting Molecular Masterpieces: The Pyrrolidine Puzzle
Explore the synthesis of novel benzoylaminocarbothioyl pyrrolidines through imine-azomethine ylide-1,3-dipolar cycloaddition cascade and their promising biological activities.